Ludong is a threatened fish species. Other than this, the river is also rich in Goby fish species called ‘Mori’, ‘Birut’, and ‘Ifun’ - which can be considered as the smallest fish species in the region; ‘Agua’ or milkfish species; and ‘Sihin’ or freshwater eel. Reports said some of these species suspected of being threatened include the ‘cabibi’, ‘unnuk’, ‘anzikkan’, ‘ala’, ‘basikul’, ‘liddag’, and ‘ararayan.’
Over-gathering and the use of chemicals in agriculture have been blamed for the state of endemic species in the province.
The mighty and at times turbulent river also supports the lives of numerous endemic and endangered fauna species, like the Luzon bleeding-heart pigeon (Gallicolumba luzonica), Philippine eagle (Pithecophaga jefferyi) as well as other species that are also considered rare and threatened.
Throughout history, the Cagayan River has played a vital role in people’s day-to-day living. It was and still is utilized as a passageway to and from municipalities and barangays.